Hormone replace therapy and changes in mammographic density in postmenopausal women.
- Author:
Sang Bum SEO
1
;
Keum Nahn JEE
;
Jin Wan PARK
Author Information
1. Department of Obstetrics and Gynecology, *Radiology, Dankook University, College of Medicine, Cheonan, Korea. parkdkog@dankook.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Hormone replace therapy;
Mammography;
Breast density
- MeSH:
Estrogens;
Female;
Humans;
Mammography
- From:Korean Journal of Obstetrics and Gynecology
2005;48(2):411-417
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the changes in mammographic density by different types of hormone replace therapy (HRT) in postmenopausal women. METHODS: A total of 150 postmenopausal women who received same HRT regimen for 1 year were classified as the four groups according to the regimen of HRT; 1) daily conjugated equine estrogen (CEE) 0.625 mg+medroxiprogesterone acetate (MPA) 2.5 mg (CEE/MPA-continuous, n=42), 2) daily CEE 0.625 mg+MPA 10 mg on days 1-12 (CEE/MPA-cyclic, n=28), 3) daily CEE 0.625 mg (CEE only, n=40), 4) daily tibolone 2.5 mg (Tibolone, n=40). And 40 women were allocated as control group. The changes in mammographic density in each group were compared with before and after HRT for 1 year. RESULTS: The increase in mammographic density after 1 year of HRT was significantly higher in CEE/MPA-continuous group and CEE/MPA-cyclic group compaired with control group (p<0.05), and was not observed in CEE only group and tibolone group. CONCLUSION: Our results suggest that greater increase of mammographic density in postmenopausal women was significantly associated with estrogen/progestin combination therapy.
