Survivin and Bcl-2 expression in eutopic endometrium with and without endometriosis.
- Author:
Yun Jin KIM
1
;
Young Ah KIM
;
Han Seong KIM
;
Woon Hee SUH
;
Kyung Koo KIM
;
Doo Young CHANG
;
Myung Kwon JEON
;
Eung Soo LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Inje University, Ilsan Paik Hospital, Kyunggi, Korea. camanbal@ilsanpaik.ac.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Endometriosis;
Eutopic endometrium;
Survivin;
Bcl-2
- MeSH:
Endometriosis*;
Endometrium*;
Epithelium;
Female;
Turkey
- From:Korean Journal of Obstetrics and Gynecology
2005;48(2):418-427
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To examine expression of survivin and Bcl-2 in eutopic endometrium with endometriosis and without endometriosis by immunohistochemical stain. METHODS: Expression of survivin and Bcl-2 was immunohistochemically investigated in eutopic endometrium with endometriosis (n=30, study group I; laparoscopy-proved endometriosis, study group II; adenomyosis) or without endometriosis (n=34, control group). The score of immunohistochemical staining was evaluated semi-quantitative method modified by Sinicrope and Lu. Statistical analyses was carried out using one-way ANOVA with Turkey test. RESULTS: Survivin expression was significantly higher in nucleus of glandular epithelium of eutopic endometrium with endomtriosis compared to that without endometriosis (p<0.05). Increased expression of Bcl-2 was found in glandular epithelium of eutopic endometrium with endometriosis than without endometriosis, but there was no significantly difference. CONCLUSION: Our findings suggest that increased survivin expression may contribute to survival of endometriosis. Moreover, survivin could play an important role in pathogenesis of endometriosis.
