A Case of Clozapine-Induced Eosinophilia Combined with Bilateral Pleural Effusion, Ascites, Cholecysctitis, and Hepatitis.
- Author:
Hyun Ju HONG
1
;
Chan Hyung KIM
;
Dong Ho SONG
;
Se Jun LEE
;
Hong Shick LEE
Author Information
1. Department of Psychiatry, Yonsei University College of Medicine, Seoul, Korea. spr88@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Clozapine;
Eosinophilia
- MeSH:
Agranulocytosis;
Ascites*;
Cholecystitis;
Clozapine;
Eosinophilia*;
Ether;
Hepatitis*;
Incidence;
Pleural Effusion*
- From:Korean Journal of Psychopharmacology
1999;10(2):191-195
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Several blood dyscrasias associated with clozapine have been well known to clinicians and potentially life threatening agranulocytosis has been widely reported. However, there is little report regarding incidence, progression and associated features of eosinophilia associated with clozapine. In clinical studies, the onset of eosinophilia usually occurs artier 3 to 5 weeks of treatment and rarely were cases fatal with medical complication. We report the first case of severe eosinophilia, bilateral pleural effusion, asicites, hepatitis and cholecystitis associated with clozapine that would be fatal. Eosinophilia occurred after 19 days of treatment with clozapine and all the clinical conditions improved along with interruption of clozapine treatment. It is suggested that eosinophilia may be more severe side effort than has ether been known and close hematologic monitoring should be done during early treatment of clozapine.
