Incidence and Risk Factors of Pneumonia in Hospitalized Patients with Seasonal Influenza A or B.
- Author:
Seongjun CHU
1
;
Sang Joon PARK
;
So My KOO
;
Yang Ki KIM
;
Ki Up KIM
;
Soo Taek UH
;
Tae Hyung KIM
;
Suyeon PARK
Author Information
- Publication Type:Original Article
- Keywords: Pneumonia; Influenza; Risk Factors; Comorbidity
- MeSH: Comorbidity; Herpesvirus 1, Cercopithecine; Hospitalization; Humans; Incidence*; Influenza, Human*; Leukocyte Count; Multivariate Analysis; Odds Ratio; Platelet Count; Pneumonia*; Polymerase Chain Reaction; Retrospective Studies; Risk Factors*; Seasons*; Sputum
- From:Tuberculosis and Respiratory Diseases 2017;80(4):392-400
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Most patients with influenza recover spontaneously or following treatment with an anti-viral agent, but some patients experience pneumonia requiring hospitalization. We conducted a retrospective review to determine the incidence and risk factors of pneumonia in hospitalized patients with influenza A or B. METHODS: A total of 213 patients aged 18 years or older and hospitalized with influenza between January 2012 and January 2015 were included in this study. A reverse-transcriptase polymerase chain reaction assay was used to detect the influenza A or B virus in the patients' sputum samples. We collected demographic and laboratory data, combined coexisting diseases, and radiologic findings. RESULTS: The incidence of pneumonia was higher in patients in the influenza A group compared to those in the influenza B group (68.6% vs. 56.9%), but this difference was not statistically significant. The presence of underlying respiratory disease was significantly associated with pneumonia in the influenza A group (adjusted odds ratio [OR], 3.975; 95% confidence interval [CI], 1.312–12.043; p=0.015). In the influenza B group, the white blood cell count (adjusted OR, 1.413; 95% CI, 1.053–1.896; p=0.021), platelet count (adjusted OR, 0.988; 95% CI, 0.978–0.999; p=0.027), and existence of an underlying medical disease (adjusted OR, 15.858; 95% CI, 1.757–143.088; p=0.014) were all significantly associated with pneumonia in multivariate analyses. CONCLUSION: The incidence of pneumonia was 65.7% in hospitalized patients with influenza A or B. The risk factors of pneumonia differed in hospitalized patients with influenza A or B.
