Comparison of insulin resistance and serum hsCRP levels according to the fasting blood glucose and blood pressure in nondiabetic and normotensive range.
- Author:
Young Choon KIM
1
;
Eun Jung RHEE
;
Tae Woo YOO
;
Sang Tai HWANG
;
Se Yong OH
;
Han Byul CHUN
;
Jeung Mook KANG
;
Seung Ho RYU
;
Won Young LEE
;
Sun Woo KIM
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hongsiri@hanmail.net
- Publication Type:Original Article
- Keywords:
Insulin resistance;
Cardiovascular disease;
CRP
- MeSH:
Blood Glucose*;
Blood Pressure*;
Body Mass Index;
C-Reactive Protein;
Cardiovascular Diseases;
Fasting*;
Female;
Glucose;
Humans;
Insulin Resistance*;
Insulin*;
Male;
Prevalence;
Reference Values;
Risk Factors
- From:Korean Journal of Medicine
2005;68(2):178-185
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Insulin resistance is a strong contributor to cardiovascular diseases. The increasing prevalence of diabetes and the subsequent complications confers a great importance to the early detection and intervention of diabetes. However, the exact roles of blood glucose and blood pressure in nondiabetic and normotensive range to vascular complications are not precisely defined. High-sensitivity C-reactive protein (hsCRP) levels have consistently been associated with various cardiovascular endpoints in a number of studies. The aim of this study was to find out whether the insulin resistance and hsCRP, a non-traditional cardiovascular risk factor, increase according to the fasting glucose and blood pressure levels in nondiabetic and normotensive individuals. METHODS: In 7,979 participants (4,847 males, 3,132 females, mean age 46 yrs) undergoing medical checkup program in Kangbuk Samsung Hospital, blood pressures, body mass index (BMI), fasting blood glucose, fasting insulin, lipid batteries and hsCRP levels were checked. All participants were subdivided into 5 groups according to fasting glucose level and into 4 groups according to the blood pressures. Homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) were calculated. RESULTS: HOMA-IR and QUICKI increased according to the increment in fasting glucose and blood pressure in nondiabetic and normotensive range (p<0.01). Log (hsCRP) level significantly increased in proportion to the increment in fasting glucose and blood pressure in nondiabetic and normotensive range (p<0.01). CONCLUSION: Insulin resistance correlated with increment in the fasting glucose and blood pressure even in nondiabetic and normotensive range. Cardiovascular risk might be increased in proportion to the increment of fasting glucose and blood pressure even in the normal range. There may not be the glycemic and hypertensive threshold for the cardiovascular risk.
