A case of paroxysmal nocturnal hemoglobinuria with recurrent acute renal failure.
- Author:
Sung Won JUNG
1
;
Yu Min LEE
;
Moo Rim PARK
;
Myeung Su LEE
;
Seung Hoon BAEK
;
Seon Ho AHN
;
Ju Hung SONG
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Korea. ashneph@wmc.wonkwang.ac.kr
- Publication Type:Case Report
- Keywords:
Paroxysmal nocturnal hemoglobinuria;
Acute renal failure
- MeSH:
Acute Kidney Injury*;
Hematopoiesis;
Hematopoietic Stem Cells;
Hemoglobinuria, Paroxysmal*;
Hemolysis;
Hemosiderin;
Kidney;
Precipitating Factors;
Rectal Fistula;
Renal Dialysis;
Venous Thrombosis
- From:Korean Journal of Medicine
2004;66(3):307-311
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paroxysmal nocturnal hemoglobinuria (PNH) is a acquired clonal disorder of the hematopoietic stem cells characterized by chronic intravascular hemolysis, venous thrombosis, deficient hematopoiesis. Kidney involvement is usually benign and secondary to chronic deposition of hemosiderin. But, acute renal failure may rarely occur in association with a hemolytic crisis or thrombotic complication. Hemolytic crisis is precipitated by nonspecific factors, such as infection, surgery and transfusion. A 69-year- old man was admitted to our hospital who developed acute renal failure after operation of anal fistula. He was diagnosed with PNH accompanied with deep vein thrombosis later. After being treated by hemodialysis and oral low dose steroid, he was discharged with full recovery of renal function. But, he frequently was developed acute renal failure with crisis of PNH despite taking low dose steroid. So, we report a case of PNH with recurrent acute renal failure without precipitating factors.
