A Case of Gastric Undifferentiated Carcinoma with Choriocarcinomatous and Hepatoid Carcinomatous Differentiation.
- Author:
Su Youn LEE
1
;
Hee Seok MOON
;
Eui Sik KIM
;
Yun Jeung KIM
;
Pyung Gohn GOH
;
Byung Seok LEE
;
Hyun Yong JEONG
;
Heon Young LEE
Author Information
1. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. mhs1357@cnuh.co.kr
- Publication Type:Case Report
- Keywords:
Gastric undifferentiated carcinoma;
Hepatoid carcinoma;
Choriocarcinoma
- MeSH:
Adenocarcinoma;
Biopsy;
Carcinoma;
Choriocarcinoma;
Chorionic Gonadotropin;
Delivery of Health Care;
Female;
Gastrectomy;
Gastroscopy;
Humans;
Lymph Nodes;
Mass Screening;
Middle Aged;
Pregnancy;
Pyloric Antrum
- From:Korean Journal of Gastrointestinal Endoscopy
2010;41(6):355-359
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Here we report a case of a patient with gastric undifferentiated carcinoma associated with choriocarcinomatous and hepatoid carcinomatous differentiation. A 62-year-old man was referred after a healthcare screening gastroscopy. Gastroscopy revealed an approximately 3x3 cm ulcerofungating mass in the posterior wall of the antrum. Biopsy results revealed a moderately differentiated adenocarcinoma. The initial serum alpha-FP levels were above 350 ng/mL. An abdominal CT scan revealed focal wall thickening along the greater curvature of the gastric antrum, with perigastric fat invasion and enlarged multiple perigastric lymph nodes. He underwent a palliative radical subtotal gastrectomy and gastroduodenostomy with dissection of the enlarged lymph nodes. Postsurgical histological examination revealed an undifferentiated carcinoma associated with choriocarcinomatous and hepatoid carcinomatous differentiation. Immunohistochemical staining revealed that the tumor cells were positive for human chorionic gonadotropin (hCG), alpha-FP, and anti-hepatocyte antibody.
