Prognostic Significance of Maspin in Pancreatic Ductal Adenocarcinoma.
- Author:
Yun Jeong LIM
1
;
Jong Kyun LEE
;
Woo Young JANG
;
Sang Yong SONG
;
Kyu Taek LEE
;
Seung Woon PAIK
;
Jong Chul RHEE
Author Information
1. Center for Health promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Maspin;
Pancreatic neoplasm;
Prognosis
- MeSH:
Adolescent;
Adult;
Aged;
Biological Markers;
Carcinoma, Pancreatic Ductal/*metabolism/surgery;
Female;
Human;
Immunohistochemistry;
Male;
Middle Aged;
Pancreatic Neoplasms/*metabolism/surgery;
Prognosis;
Proteins/*metabolism;
Serpins/*metabolism
- From:The Korean Journal of Internal Medicine
2004;19(1):15-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Maspin is a serpin family of protease inhibitors. Althouth maspin has been considered a tumor suppressor that inhibits the motility, invasion, and metastasis of breast and prostatic cancer cells, there are many conflicting reports about maspin expression and cancer prognosis. METHODS: To investigate whether the expression of maspin could be used as a prognostic marker in pancreatic cancer, 72 paraffin-embedded pancreatic ductal adenocarcinomas were analyzed using immunohistochemistry. We examined the prognostic value of maspin as well as its relationship with clinicopathological features. RESULTS: Maspin expression was observed in all pancreatic ductal adenocarcinoma. Unlike cancer tissues, however, faint or no expression was observed in the corresponding normal pancreatic tissues. In the Cox proportional hazard model, high maspin expression predicted a high hazard rate. Maspin expression had a positive correlation with tumor stage, but there were also no statistically significant relationships between maspin expression and other clinicopathological features. CONCLUSION: These findings suggest maspin expression to have biological relevance in the progression of pancreatic cancers, with potential use as a prognostic marker for pancreatic neoplasm with epithelial origin.
