Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma.
- Author:
Eunhyang PARK
1
;
Soo Young PARK
;
Hyojin KIM
;
Ping Li SUN
;
Yan JIN
;
Suk Ki CHO
;
Kwhanmien KIM
;
Choon Taek LEE
;
Jin Haeng CHUNG
Author Information
- Publication Type:Original Article
- Keywords: Carcinoma, non-small-cell lung; Insulin-like growth factor-1 receptor; Receptor, epidermal growth factor; Immunohistochemistry; Membranous expression
- MeSH: Adenocarcinoma*; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cytoplasm; Disease-Free Survival; Epidermal Growth Factor*; Humans; Immunohistochemistry; Lung; Membranes; Prognosis*; Protein-Tyrosine Kinases; Receptor, Epidermal Growth Factor*
- From:Journal of Pathology and Translational Medicine 2015;49(5):382-388
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Insulin-like growth factor-1 receptor (IGF1R) is a membrane receptor-type tyrosine kinase that has attracted considerable attention as a potential therapeutic target, although its clinical significance in non-small cell lung cancer (NSCLC) is controversial. This study aimed to clarify the clinical significance of IGF1R expression in human NSCLC. METHODS: IGF1R protein expression was evaluated using immunohistochemistry in 372 patients with NSCLC who underwent curative surgical resection (146 squamous cell carcinomas [SqCCs] and 226 adenocarcinomas [ADCs]). We then analyzed correlations between expression of IGF1R and clinicopathological and molecular features and prognostic significance. RESULTS: Membranous and cytoplasmic IGF1R expression were significantly higher in SqCCs than in ADCs. In patients with SqCC, membranous IGF1R expression was associated with absence of vascular, lymphatic, and perineural invasion; lower stage; and better progression-free survival (PFS) (hazard ratio [HR], 0.586; p = .040). In patients with ADC, IGF1R expression did not have a significant prognostic value; however, in the subgroup of epidermal growth factor receptor (EGFR)-mutant ADC, membranous IGF1R expression was associated with lymphatic and perineural invasion, solid predominant histology, and higher cancer stage and was significantly associated with worse PFS (HR, 2.582; p = .009). CONCLUSIONS: Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while it was predictive of better PFS in SqCC. These findings will help improve study design for subsequent investigations and select patients for future anti-IGF1R therapy.
