Oncocytic Renal Cell Carcinoma with Tubulopapillary Growth Having a Fat Component.
- Author:
Na Rae KIM
1
;
Hyun Yee CHO
Author Information
- Publication Type:Case Report
- Keywords: Oxyphil cells; Carcinoma, renal cell; Adipocytes; Mycobacterium tuberculosis
- MeSH: Adipocytes; Amylases; Carcinoma, Renal Cell*; Cytoplasm; Diagnostic Errors; Eosinophils; Humans; Hyalin; Kidney Failure, Chronic; Melanoma; Mitochondria; Mycobacterium tuberculosis; Oxyphil Cells; Transcription Factors; Vimentin
- From:Journal of Pathology and Translational Medicine 2015;49(5):413-417
- CountryRepublic of Korea
- Language:English
- Abstract: We report a rare case of oncocytic renal cell carcinoma (RCC) with tubulopapillary growth in the background of tuberculous end-stage kidney disease. Histology of the renal mass consisted of oncocytic cells forming solid, thin tubules and rare papillae. The tumor had abundant eosinophilic oncocytic cells containing occasional cytoplasmic Mallory body-like hyaline globules and a tiny focus of clear cells with intervening mature fat. Both the oncocytic cells and clear cells were immunoreactive for a-methylacyl-CoA racemase, vimentin, pancytokeratin, and CD10, and negative for transcription factor E3, CD15, human melanoma black 45, and c-kit. Mallory body-like hyaline globules were positive for CAM 5.2 and periodic acid-Schiff with or without diastase. Ultrastructurally, the tumor cells had abundant cytoplasmic mitochondria. The present case is a rare case of oncocytic RCC with tubulopapillary growth pattern. The case is unique in that the tumor was mixed with fat component, which is not common in RCC and thus can lead to misdiagnosis.
