Delayed Hemolytic Transfusion Reaction with Alloimmunization of Rh Phenotype: A Two-Case Study.
10.17945/kjbt.2017.28.2.163
- Author:
Dong Won YOO
1
;
Hyun Ji LEE
;
Sun Min LEE
;
In Suk KIM
;
Duyeal SONG
;
Chulhun L CHANG
;
Kyung Hwa SHIN
;
Hyung Hoi KIM
Author Information
1. Department of Laboratory Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea. hilhj1120@gmail.com
- Publication Type:Case Report
- Keywords:
Alloimmunization;
Delayed hemolytic transfusion reactions;
Rh subgroup;
Unexpected antibody
- MeSH:
Antibodies;
Antibody Formation;
Blood Group Antigens;
Blood Transfusion;
Humans;
Phenotype*;
Transfusion Reaction*
- From:Korean Journal of Blood Transfusion
2017;28(2):163-169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Delayed hemolytic transfusion reaction is difficult to prevent using an unexpected antibody test performed prior to transfusion, and unlike acute hemolytic transfusion reaction, it occurs a few days after blood transfusion. Hence, determining the reason for delayed hemolytic transfusion reaction may be a tim-consuming task for clinicians Here, we report our experience of two cases of delayed hemolytic transfusion reaction as a result of the unexpected antibody production to Rh blood group antigens after transfusion. The first patient with a history of transfusion during admission was identified as having anti-E and anti-C antibodies according to the antibody identification test at the time of re-admission. The second patient who had chronic blood transfusion due to cancer treatment was found to have anti-C antibody. Both patients received transfusion of Rh antigen-compatible RBC units only after unexpected antibody development. However, like both cases, patients receiving continuous blood transfusion should be considered for a routine Rh phenotype test.
