Associations among Body Mass Index, Insulin Resistance, and Pancreatic beta-Cell Function in Korean Patients with New-Onset Type 2 Diabetes.
10.3904/kjim.2012.27.1.66
- Author:
Jin Ook CHUNG
1
;
Dong Hyeok CHO
;
Dong Jin CHUNG
;
Min Young CHUNG
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. mychung@chonnam.ac.kr
- Publication Type:Original Article
- Keywords:
Body mass index;
Insulin resistance;
Secretion;
Diabetes mellitus, type 2
- MeSH:
*Asian Continental Ancestry Group;
Biological Markers/blood;
Blood Glucose/metabolism;
*Body Mass Index;
Diabetes Mellitus, Type 2/blood/diagnosis/*ethnology/physiopathology;
Female;
Glucose Tolerance Test;
Hemoglobin A, Glycosylated/metabolism;
Humans;
Insulin/blood;
Insulin Resistance/*ethnology;
Insulin-Secreting Cells/*metabolism;
Linear Models;
Logistic Models;
Male;
Middle Aged;
Multivariate Analysis;
Predictive Value of Tests;
Republic of Korea/epidemiology;
Risk Assessment;
Risk Factors
- From:The Korean Journal of Internal Medicine
2012;27(1):66-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes. METHODS: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. RESULTS: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMA-IR), homeostasis model assessment of beta-cell function (HOMA-beta), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-beta and inverse associations with the DI. CONCLUSIONS: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with beta-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.
