An Elevated Value of C-Reactive Protein is the Only Predictive Factor of Restenosis after Percutaneous Coronary Intervention.
- Author:
Woo Kon JEONG
1
;
Myung Ho JEONG
;
Kye Hun KIM
;
Sang Rok LEE
;
Ok Young PARK
;
Ju Hyup YUM
;
Joo Han KIM
;
Won KIM
;
Jae Young RHEW
;
Youn Keun AHN
;
Jeong Gwan CHO
;
Byoung Hee AHN
;
Soon Pal SUH
;
Jong Chun PARK
;
Sang Hyung KIM
;
Jung Chaee KANG
Author Information
1. The Heart Center, Chonnam National University Hospital, The Research Institute of Medical Sciences, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article ; Comparative Study
- Keywords:
Coronary Artery Disease;
Restenosis;
C-Reactive Protein;
Percutaneous Coronary Intervention
- MeSH:
*Angioplasty, Transluminal, Percutaneous Coronary;
Antibodies, Bacterial/blood;
Antibodies, Viral/blood;
Biological Markers/analysis;
C-Reactive Protein/*analysis;
Chlamydophila pneumoniae/immunology;
Comparative Study;
Coronary Angiography;
Coronary Restenosis/*blood/diagnosis/*therapy;
Cytomegalovirus/immunology;
Female;
Helicobacter pylori/immunology;
Human;
Male;
Middle Aged;
Predictive Value of Tests;
Prognosis;
Prospective Studies;
Recurrence
- From:The Korean Journal of Internal Medicine
2003;18(3):154-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The current techniques for percutaneous coronary interventions (PCI) remain limited by restenosis. Recent studies have provided evidence of inflammation playing a role in the pathogenesis of cardiovascular disease. METHODS: Whether inflammatory markers are predictors of subsequent restenosis were prospectively tested in 272 consecutive patients with angiographically proven coronary artery disease. Patients having undergone PCI at Chonnam National University Hospital, between Sept. 1999 and Mar. 2001, were divided into two groups according to the occurrence of restenosis on a follow-up coronary angiogram: Group I were patients with restenosis (n=99, 59.5 +/- 10.8 years, M: F=77: 22) and Group II were those without restenosis (n=173, 58.8 +/- 10.2 years, M: F=131: 42). The IgG seropositivity, cytomegalovirus (CMV) titers, C. pneumoniae, H. pylori and levels of C-reactive protein (CRP) were compared between the two groups. RESULTS: There were no statistical differences in the seropositivity of the CMV IgG C. pneumoniae IgG and H. pylori IgG between the two groups (Groups I vs. II: 100 vs. 100%, 24.7 vs. 25.7% and 62.2 vs. 63.7%, respectively). Of the angiographic parameters, a low Thrombolysis In Myocardial Infarction (TIMI) flow (TIMI 0 or I) was more common in Group I than Group II (p=0.038). The patients with an elevated CRP (> 0.5 mg/dL) were more common in Group I than Group II (57.6 vs. 36.4%, p=0.001), with the CRP values being higher in Group I than Group II (3.3 +/- 5.8 vs. 1.3 +/- 2.6 mg/dL, p=0.001). According to a multiple logistic regression analysis, the CRP was the only predictor of restenosis, with an odds ratio of 2.1169 (95% C.I. 1.2062-3.7154, p=0.009). CONCLUSION: The CRP value is the most important predictor of restenosis after PCI.
