Long Term Effectiveness of Doxazosin in Men with Lower Urinary Tract Symptoms Suggesting of Benign Prostatic Hyperplasia.

Author: Jun CHOI ¹ ; Jeong Oh LEE ; Bo Hyun HAN ; Hyuk Soo CHANG
Author Information

1. Department of Urology, Maryknoll Hospital, Busan, Korea.
Publication Type:Original Article
Keywords: Benign prostatic hyperplasia; Doxazosin
MeSH: Male; Humans
From:Korean Journal of Urology 2008;49(11):1003-1006
CountryRepublic of Korea
Language:Korean
Abstract: PURPOSE: The aim of this study was to evaluate the efficacy of doxazosin over 6 years in men with benign prostatic hyperplasia(BPH). MATERIALS AND METHODS: This retrospective study enrolled 33 patients with symptomatic BPH who were prescribed an alpha-blocker from January 1999 to December 2000. We evaluated the changes of International Prostate Symptom Score(IPSS), maximal flow rate(Qmax), quality of life(QoL) and residual urine volume(RUV) between before and after 6-year of treatment. RESULTS: The percentages of improvement were 40.2% in total IPSS, 40.6% in obstructive symptom, 39.4% in irritative symptom, 44.7% in QoL, 124.8% in Qmax, 33.5% in RUV(p<0.05). Three patients(9.1%) experienced acute urinary retention and BPH-related surgery was performed in 6 patients (18.2%). CONCLUSIONS: Our study revealed that long-term treatment over 6 years with alpha-blocker resulted in significant improvements in the IPSS, QoL, Qmax and RUV.