Long-term Outcome of Graft Rejection after Penetrating Keratoplasty.
- Author:
Mee Kum KIM
1
;
Jin Hak LEE
Author Information
1. Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Keratoplasty;
Rejection;
risk factor;
Survival rate
- MeSH:
Corneal Neovascularization;
Corneal Transplantation;
Corneal Ulcer;
Diagnosis;
Glaucoma;
Graft Rejection*;
Graft Survival;
Humans;
Keratitis, Herpetic;
Keratoconus;
Keratoplasty, Penetrating*;
Multivariate Analysis;
Retrospective Studies;
Risk Factors;
Seoul;
Survival Rate;
Sutures;
Tissue Donors;
Transplants*;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
1997;38(9):1553-1560
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We retrospectively analyzed long-term outcome of graft rejection after penetrating keratoplasty in 128 eyes of 110 patients at Seoul National University Hospital, over 66 months period. The most common preoperative diagnosis of recipients was keratoconus, and aphakic bullous keratopathy, herpes simplex keratitis and corneal ulcer were in order. The results obtained are as follows : The rejection rate was 45.3% (58 eyes) in all of the graft, and it was 35.1% in keratoconus. Graft rejection developed in 52 eyes(92.1%) within 1 year and two eyes after 3 years, and a eyes at 5 years after graft. Graft rejection was reversed in 39.7% (23 eyes) of all graft rejection cases and 75%(15 eyes) in keratoconus. Best corrected visual acuity of 100/200 or better was achieved by 64.9%, and that of keratoconus was 82.5%. In univariate analysis of graft survival, peripheral anterior synechia, previous history of glaucoma, the presence of combined operation, technique of suture, corneal neovascularization showed high correlation with graft rejection however donor age, recipient age, re-keratoplasty and the size of donor corneal button didn`t show correlation with development of graft rejection. In multivariate analysis of graft survival, previous history of glaucoma, lens status and the presence of combined operation showed high correlation with graft rejection.
