Expressions of E2F4 and E2F2 Transcription Factors in Breast Carcinoma.
- Author:
Eun Young KIM
1
;
Hyun Jin JO
;
Mi Ja LEE
Author Information
1. Department of Pediatrics, College of Medicine, Chosun University, Gwangju, Korea.
- Publication Type:Original Article
- Keywords:
Breast cancer;
E2F4 transcription factor;
E2F2 transcription factor;
Immunohistochemistry
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinogenesis;
Cell Cycle;
Cyclin D1;
DNA;
E2F2 Transcription Factor*;
E2F4 Transcription Factor;
Genes, Tumor Suppressor;
Humans;
Immunohistochemistry;
Lymph Nodes;
Neoplasm Metastasis;
Oncogenes;
Ploidies;
Prognosis;
Transcription Factors
- From:Korean Journal of Pathology
2005;39(5):301-306
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The E2F family (E2F1 to E2F6) of transcription factors plays a key role in cell cycle progression. Some act as oncogenes and others act as tumor suppressor genes (TSG) in a tissue-specific manner. E2F4 may function as a TSG. However, the role of E2F4 in breast carcinogenesis remains controversial. Also the clinical impact of E2F2 expression on breast cancer remains unknown. METHODS: Expressions of E2F4 and E2F2 were assessed immunohistochemically in 113 breast carcinomas and were compared with clinicopathological variables, expressions of G1/S checkpoint proteins (p16, cyclin D1 and Rb), and DNA ploidy to identify their possible role and to assess their prognostic value in breast cancer. RESULTS: Expressions of E2F4 and E2F2 were detected in 48 cases (42.5%) and 66 cases (58.4%), respectively. Expressions of E2F4 and E2F2 were significantly correlated with large tumor size (p<0.001) and lymph node metastasis (p<0.001). There was no correlation between expressions of E2F4 or E2F2 and any other variables, including age, histologic grade, DNA ploidy and expressions of p16, cyclin D1 and Rb. CONCLUSIONS: These results suggest that expressions of E2F4 and E2F2 are associated with growth and spread of breast cancer and indicate poor prognosis.
