Survivin and Fas Ligand Expressions Are Correlated with Angiolymphatic Tumor Spread in Medullary Thyroid Carcinoma.
- Author:
Min Kyung KIM
1
;
Jin Hee SOHN
;
Mee JOO
;
Hanseung KIM
;
Sung Hye PARK
;
Seong Hoe PARK
;
Eo Jin KIM
;
Seoung Wan CHAE
Author Information
1. Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. swan.chae@samsung.com
- Publication Type:Original Article
- Keywords:
Survivin protein;
Thyroid gland;
Carcinoma, medullary
- MeSH:
Antibodies;
Calcitonin;
Carcinoma, Medullary;
Cyclin A;
Cyclins;
Fas Ligand Protein*;
Lymph Nodes;
Multiple Endocrine Neoplasia;
Neoplasm Metastasis;
Proto-Oncogenes;
Thyroid Gland*;
Thyroid Neoplasms*
- From:Korean Journal of Pathology
2005;39(5):320-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Medullary thyroid carcinoma (MTC) that originates from C cells comprises about 10% of all the malignant thyroid tumors. Activating mutations of the RET proto-oncogene have been found to be involved in the anti-apoptotic pathway of MTC that harbors the RET mutation. We investigated the correlation between the clinicopathologic parameters and the expressions of survivin, a novel anti-apoptotic molecule, and the other apoptosis-related proteins, and the known prognostic markers. METHODS: Immunohistochemical staining was performed using antibodies for survivin, Fas, Fas ligand (FasL), bcl-2, calcitonin, CEA and cyclin A in 19 case of MTC; 10 sporadic MTCs, eight multiple endocrine neoplasia (MEN) type 2A MTCs and one familial MTC (FMTC). RESULTS: Survivin protein expression was found in five cases (26%) and this was correlated with the presence of angiolymphatic tumor emboli (p=0.019). FasL was expressed in 14 cases (74%) and it had correlation with the presence of lymph node metastases (p=0.029). The cyclin A-labeling indices were correlated with local invasiveness (p=0.001). CONCLUSIONS: Survivin and FasL might be involved in the lymphatic tumor spread of MTC.
