The Relationship Between the Serum Level of Cytokines (Interleukin-2, Interleukin-6, Interleukin-10, Interferon-gamma) and the Erythematous Induration of BCG Site in the Children with Kawasaki Disease.
- Author:
Sung Hoon KIM
1
;
June HUH
;
I Seok KANG
;
Heung Jae LEE
Author Information
1. Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. herzhuh@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Kawasaki disease;
Cytokine;
Bacillus Calmette-Guerin
- MeSH:
Age of Onset;
Child*;
Coronary Vessels;
Cytokines*;
Diagnosis;
Humans;
Interferon-gamma;
Interleukin-10*;
Interleukin-2;
Interleukin-6*;
Mucocutaneous Lymph Node Syndrome*;
Mycobacterium bovis*;
Skin
- From:Journal of the Korean Pediatric Cardiology Society
2006;10(2):189-195
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was aimed to investigate the clinical findings and the changes of serum levels of inflammatory cytokines according to the presence of erythematous induration at BCG (Bacillus Calmette-Guerin) site in the children with Kawasaki disease. METHODS: Thirty-one patients with Kawasaki disease were classified into a group with erythematous induration at BCG site (BCG (+), n=14, M: F=11: 3) and a group without skin changes at BCG site (BCG (-), n=17, M: F=12: 5). Levels of various laboratory parameters and cytokines including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10) and interferon-gamma (IFN-gamma) were determined four times on admission day, 3-4 days, 2 weeks and 8 weeks after intravenous immunoglobuin injection. RESULTS: The age of onset in BCG (+) group was significantly younger than BCG (-) group (15+/-8 months vs. 31+/-16 months, P<0.05). There were no significant differences in other clinical findings and laboratory parameters except elevated ESR in BCG (-) group. There was no difference in complications of coronary arteries and cardiac function between two groups. The serum levels of IL-2, IL-6 and IL-10 were increased in all patients at the diagnosis, but there were no significant differences between BCG (-) and BCG (-) groups. The serial changes of cytokines did not show any significant differences. CONCLUSION: In Kawasaki disease, BCG site injection seems to develop in younger age and not to be related to the differences of immunologic inflammatory response.
