The Effect of Small Doses of Oral Corticosteroids in Vitiligo Patients.
- Author:
Tae Kee MOON
;
Sung Bin IM
;
Seung Kyung HANN
;
Sung Hwan CHO
;
Yoon Kee PARK
- Publication Type:Original Article
- Keywords:
Vitiligo;
Systemic corticosteroid
- MeSH:
Adrenal Cortex Hormones*;
Humans;
Prednisolone;
Vitiligo*
- From:Korean Journal of Dermatology
1995;33(5):880-885
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: One of the most, probable pathogenesis of vitiliga is autoimmune. Systemic cor tico st,eroids suppress immunity and may arrest the progression of vitiligo and lead to repigmentation. OBJECTIVE: We have assessed the clinical effect of a oral small oral dose of corticosteroid to minimize side effects in vitiligo patients. METHODS: Thirty four patients(9;male, 25;female) with vitiligo were evaluated in this study. The patients took 7.5mg-20mg prednisolone initially for 2 months and then the dosage was tapered to half of the initial dosiat the 3rd month and half of dose of 3rd month for the last 4th month. We compared the effcct of treatment of vitiligo before and aft.er the study by photographs. and side efferts were issessed at. 1, 2, 3 and 4 month. RESULTS: The arrest of the progression of vitiligo was noticed in 79% of patients and repigmentation was noticed in 59% of patients which is statistically significant. The effect, of treatment according to extent, duiation, type, and site of vitiligo were not statistically significant. The side effects of treatment were minimal and did not affect the course of treatment. CONCLUSION: Small doses of iral corticosteroids are effective without any significant side effects in preventing progression and loiiduce repigmentation of active spreading vitiligo and generalized type of vitiligo that is difficult to treat with topical corticosteroids.
