Clinical significance of insulin-like growth factor-1 receptor expression in stage I non-small-cell lung cancer: immunohistochemical analysis.
10.3904/kjim.2008.23.3.116
- Author:
Chang Youl LEE
1
;
Jeong Hee JEON
;
Hyung Jung KIM
;
Dong Hwan SHIN
;
Tae Woong ROH
;
Chul Min AHN
;
Yoon Soo CHANG
Author Information
1. Department of Internal Medicine1, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
IGF;
IGF-1R;
Immunohistochemistry;
NSCLC
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Animals;
Carcinoma, Non-Small-Cell Lung/*immunology/mortality/pathology;
Female;
Humans;
Immunohistochemistry;
Insulin-Like Growth Factor I/*biosynthesis;
Male;
Mice;
Middle Aged;
Neoplasm Metastasis;
Neoplasm Staging;
Prognosis;
Receptor, IGF Type 1/*biosynthesis
- From:The Korean Journal of Internal Medicine
2008;23(3):116-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The insulin-like growth factor (IGF) system has been implicated in tumor growth, invasion, and metastasis. However, reports on the IGF-1 receptor (IGF-1R) based on radioimmunoassays are conflicting, and its prognostic implications in non-small-cell lung cancer (NSCLC) are still controversial. METHODS: Seventy-one paraffin-embedded tissue sections from stage I NSCLC patients were stained using a mouse monoclonal antibody against human IGF-1R. RESULTS: The intensity and frequency of IGF-1R expression on the membrane and cytoplasm of cancer cells was evaluated and scored using a semiquantitative system. IGF-1R expression was detected in nine of 71 (12.7%) cases. No significant relationship was found between clinical/histopathological parameters and IGF-1R expression. None of the patients whose tumor expressed IGF-1R had experienced distant metastasis or cancer-related death, although the difference did not reach statistical significance. CONCLUSIONS: We conclude that IGF-1R expression may not be a major prognostic factor for stage I NSCLC.
