Ischemia-modified albumin (IMA) is not useful for detecting myocardial ischemia during symptom-limited exercise stress tests.
10.3904/kjim.2008.23.3.121
- Author:
June Hong KIM
1
;
Jae Hoon CHOI
;
Hyun Kook LEE
;
Woo Hyung BAE
;
Kook Jin CHUN
;
Yun Seong KIM
;
Sang Kwon LEE
;
Hyung Hoi KIM
;
Taek Jong HONG
;
Yong Woo SHIN
Author Information
1. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Ischemia-modified albumin;
Exercise ECG test;
Ischemic heart disease
- MeSH:
Aged;
Albumins/*diagnostic use/metabolism;
*Chest Pain;
Electrocardiography;
*Exercise Test/instrumentation;
Female;
Humans;
Lactic Acid/blood;
Male;
Middle Aged;
Myocardial Ischemia/blood/*diagnosis/physiopathology;
Pilot Projects
- From:The Korean Journal of Internal Medicine
2008;23(3):121-126
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: We examined the ischemia-modified albumin (IMA) level during exercise in patients with coronary artery disease (CAD). METHODS: Forty patients with a history of chest pain underwent both symptom-limited treadmill exercise stress testing and coronary angiography within one week. During the treadmill tests, blood samples were obtained at baseline and 5 min after exercise to measure the serum IMA level. RESULTS: Of the 40 patients, fourteen (35%, CAD group) had significant coronary artery stenosis, while the other 26 (65%, non-CAD group) did not. The baseline and post-exercise IMA levels in the two groups did not differ significantly (105.2+/-7.2 vs. 107.7+/-6.7 U/mL at baseline and 93.1+/-10.1 vs. 94.8+/-5.7 U/mL at post-exercise in the CAD and non-CAD groups, p=0.29 and 0.57, respectively). The changes in IMA after exercise did not differ either (-10.4+/-7.5 vs. -14.0+/-7.6 U/mL in the CAD and non-CAD groups, respectively, p=0.10). Similarly, the change in IMA between the exercise ECG test positive (TMT positive, n=9) and negative (TMT negative, n=20) groups did not differ (-14.63+/-5.19, vs -8.50+/-9.01 U/mL, p=0.15, in the TMT positive and negative groups, respectively). CONCLUSIONS: Our results suggest that IMA has limitation in detecting myocardial ischemia during symptom-limited exercise stress tests.
