A Case with Primary Biliary Cirrhosis.
- Author:
Kwon CHOI
1
;
Seung O SONG
;
Hyen Ju UM
;
Seung Won LEE
;
Sung Chun SIM
;
Chang Young PARK
;
Byung Ik KIM
;
Sang Jong LEE
;
Myeong Sook KIM
Author Information
1. Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan university collage of medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Primary biliary cirrhosis;
Antimitochondrial antibodies;
Pruritus
- MeSH:
Aged;
Antibodies;
Asia;
Autoimmunity;
Bile Ducts, Intrahepatic;
Female;
Fibrosis;
Humans;
Inflammation;
Lethargy;
Liver Cirrhosis, Biliary*;
Liver Diseases;
Liver Transplantation;
Mouth;
Prevalence;
Pruritus
- From:Korean Journal of Medicine
1998;55(5):934-939
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary biliary cirrhosis (PBC) is a chronic progressive disease, more often affecting women, characterised by progressive destruction of the small intrahepatic bile ducts with portal inflammation leading to fibrosis and cirrhosis. There is a close association between PBC and antibodies to antimitochondrial antibodies (AMA). The pathogenesis of PBC remains uncertain. The disease has been considered as an example of autoimmunity. Estimates of disease prevalence vary between 20 and 240 cases per milion per year. PBC is a extremely rare liver disease in Asia. There is no definitive drug treatment, liver transplantation is indicated for patients with intractable symptoms and for end-stage disease. The authors have experienced a case of PBC in 66 year-old female who suffered from lethargy, pruritus and dry mouth since 2 years ago. We report a case of PBC with a review of literatures.
