Association between Metabolic Syndrome and Microalbuminuria in Korean Adults.
10.4082/kjfm.2015.36.2.60
- Author:
Hyun Ok LEE
1
;
Hyun Ju BAK
;
Jin Young SHIN
;
Yun Mi SONG
Author Information
1. Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yunmisong@skku.edu
- Publication Type:Original Article
- Keywords:
Metabolic Syndrome;
Albuminuria;
Hypertension;
Obesity;
Dyslipidemias
- MeSH:
Adult*;
Albuminuria;
Cross-Sectional Studies;
Dyslipidemias;
Female;
Humans;
Hypertension;
Joints;
Korea;
Logistic Models;
Male;
Nutrition Surveys;
Obesity;
Prevalence;
Renal Insufficiency, Chronic;
Risk Factors;
Weights and Measures
- From:Korean Journal of Family Medicine
2015;36(2):60-71
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: We conducted a population-based cross-sectional study of Korean adults to evaluate the association between metabolic syndrome and microalbuminuria as a marker for early-stage chronic kidney disease. METHODS: A total of 8,497 adults (3,625 men and 4,872 women) who participated in the Korea National Health and Nutrition Examination Survey between 2011 and 2012 were included. Metabolic syndrome was defined according to recommendation from a joint interim statement of international organizations published in 2009. Microalbuminuria was defined as a urinary albumin-to-creatinine ratio of 30 to 300 mg/g. The association between metabolic syndrome and microalbuminuria was evaluated using logistic regression analysis with adjustment for covariates while considering sampling weights and the complex survey design. RESULTS: The prevalence of microalbuminuriain subjects with metabolic syndrome was 11% for men and 14.4% for women, whereas the prevalence in subjects without metabolic syndrome was 3.1% for men and 6.7% for women. Metabolic syndrome was significantly associated with an increased risk of microalbuminuriain both women (odds ratio, 2.79; 95% confidence interval, 2.01 to 3.88) and men (odds ratio, 3.00; 95% confidence interval, 2.11 to 4.27). All components of the metabolic syndrome were associated with a significantly increased risk of microalbuminuria with the strongest association for high blood pressure. The risk of microalbuminuria increased in a dose-dependent manner (P-value for trend < 0.001) with the number of metabolic syndrome components observed for both sexes. CONCLUSION: These findings suggest that metabolic syndrome is a risk factor for chronic kidney disease from an early stage.
