Incidence and Predictive Factors of Central Neck Node Metastasis in Patients with T1, T2 Papillary Thyroid Cancer.
10.16956/kjes.2015.15.1.10
- Author:
Kang Ho BAE
1
;
Soon Young TAE
;
Byung Kyun KO
;
Yon Seon KIM
Author Information
1. Department of Surgery, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea. drsun@korea.com
- Publication Type:Original Article
- Keywords:
Papillary thyroid carcinoma;
Thyroidectomy;
Central lymph node metastasis
- MeSH:
Humans;
Incidence*;
Lymph Node Excision;
Lymph Nodes;
Male;
Multivariate Analysis;
Neck Dissection;
Neck*;
Neoplasm Metastasis*;
Retrospective Studies;
Risk Factors;
Thyroid Neoplasms*;
Thyroidectomy
- From:Korean Journal of Endocrine Surgery
2015;15(1):10-14
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Thyroidectomy without prophylactic central neck dissection may be recommended for small (T1 or T2) papillary thyroid carcinoma (PTC). The aim of this study was to determine the incidence and predictive factors of central cervical lymph node metastasis in T1/2 papillary thyroid carcinoma. METHODS: A retrospective review of 877 patients with T1/2 PTC who underwent thyroidectomy and central lymph node dissection with or without lateral lymph node dissection from March 2007 to February 2014 was performed. The clinicopathologic results were reviewed and the incidence and predictive factors of central cervical lymph node metastasis (LNM) were analyzed. RESULTS: The overall frequency of central LNM was 29.8%. In univariate analysis, male, younger age, bilaterality, multifocality, larger tumor size, lymphovascular invasion, and lateral lymph node metastasis were associated with central LNM. In multivariate analysis, younger age, larger tumor size, lymphovascular invasion, and lateral lymph node metastasis were independent variables of central LNM. CONCLUSION: Central LNM is associated with younger age, larger tumor, lymphovascular invasion, and lateral lymph node metastasis in small (T1/2) PTC patients. Prophylactic central lymph node dissection should be considered in patients with risk factors.
