A Case of Ischemic Skin Necrosis after Glypressin Therapy in Liver Cirrhosis.
- Author:
Ji Eun OH
1
;
Jung Soo HA
;
Dae Hyeon CHO
;
Gil Jong YU
;
Sang Goon SHIM
Author Information
1. Department of Internal Medicince, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. jeoh78@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Terlipressin;
Ischemic complications;
Cirrhosis
- MeSH:
Aged;
Fatal Outcome;
Hematemesis/diagnosis;
Hemorrhage/drug therapy;
Humans;
Ischemia/*chemically induced/*pathology;
Liver Cirrhosis/*complications;
Lysine Vasopressin/administration & dosage/adverse effects/*analogs & derivatives/therapeutic use;
Male;
Melena/diagnosis;
Necrosis;
Skin/*blood supply/drug effects/*pathology;
Vasoconstrictor Agents/administration & dosage/*adverse effects/therapeutic use
- From:The Korean Journal of Gastroenterology
2008;51(6):381-384
- CountryRepublic of Korea
- Language:English
-
Abstract:
Terlipressin is a synthetic analogue of vasopressin, which has been used in the treatment of acute variceal hemorrhage. In contrast to vasopressin, terlipressin can be administered as intermittent injections instead of continuous intravenous infusion. Thus, it has a less adverse reaction than vasopressin. We report a case of ischemic skin complication in a cirrhotic patient treated with terlipressin. A 71-year-old man with liver cirrhosis was admitted because of hematemesis and melena. He was commenced on terlipressin at a dose 1 mg every 6 hours for the treatment of varicieal bleeding. After 36 hours of treatment, skin blistering and ecchymosis was noted on the skin of his upper thigh, scrotal area and trunk. We found that terlipressin was a possible cause of ischemic skin complication based on the skin biopsy finding. Terlipressin may induce a complication of the ischemic event. In spite of rarity, special attention needs to paid on the peripheral ischemic complication of terlipressin.
