Combined Anti-VEGF and C3F8 Injection for Large Submacular Hemorrhage Secondary to Age-Related Macular Degeneration.
10.3341/jkos.2013.54.3.443
- Author:
Min Young LEE
1
;
Won Moon SEO
;
Yul Je CHOI
Author Information
1. Department of Ophthalmology, Dongkang Medical Center, Ulsan, Korea. mdseowm@msn.com
- Publication Type:Original Article
- Keywords:
Age-related macular degeneration;
Anti-VEGF;
C3F8 gas;
Submacular hemorrhage
- MeSH:
Displacement (Psychology);
Eye;
Follow-Up Studies;
Hemorrhage;
Humans;
Intravitreal Injections;
Macular Degeneration;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2013;54(3):443-448
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of intravitreal expansile gas (C3F8) with anti-VEGF injection for the treatment of large submacular hemorrhage (SMH) secondary to age-related macular degeneration (ARMD). METHODS: In this report, 18 eyes of 18 patients with large SMH secondary to ARMD were treated with a simultaneous injection of 0.3 cc C3F8 and 0.05 ml anti-VEGF intravitrealy. RESULTS: The mean age was 64.89 +/- 5.68 years and the mean size of SMH was 4.44 +/- 1.25 disc diameters (DD). The minimum follow-up period was 12 months (range: 12-17 months). Mean preoperative best corrected visual acuity (BCVA) was 1.72 +/- 0.56 log MAR which improved significantly to 1.01 +/- 0.68 log MAR at 12 months (p = 0.002). SMH displacement occurred in all eyes. BCVA improved 2 or more lines in 11 eyes (61.1%) and deteriorated in 1 eye (5.6%). CONCLUSIONS: In this report, intravitreal injection of an expansible gas (C3F8) with anti-VEGF produced successful results in anatomical displacement of SMH and early visual improvement.
