Biology of SNU Cell Lines.
- Author:
Ja Lok KU
1
;
Jae Gahb PARK
Author Information
1. Korean Cell Line Bank, Laboratory of Cell Biology, Cancer Research Center and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. jgpark@plaza.snu. ac.kr
- Publication Type:Review
- Keywords:
SNU;
Cell line;
Cell culture;
Cancer;
Cancer research
- MeSH:
Biliary Tract;
Biology*;
Brain Neoplasms;
Carcinoma, Hepatocellular;
Carcinoma, Renal Cell;
Carcinoma, Squamous Cell;
Cell Culture Techniques;
Cell Line*;
Colorectal Neoplasms;
Epigenomics;
Humans
- From:Cancer Research and Treatment
2005;37(1):1-19
- CountryRepublic of Korea
- Language:English
-
Abstract:
SNU (Seoul National University) cell lines have been established from Korean cancer patients since 1982. Of these 109 cell lines have been characterized and reported, i.e., 17 colorectal carcinoma, 12 hepatocellular carcinoma, 11 gastric carcinoma, 12 uterine cervical carcinoma, 17 B-lymphoblastoid cell lines derived from cancer patients, 5 ovarian carcinoma, 3 malignant mixed Mllerian tumor, 6 laryngeal squamous cell carcinoma, 7 renal cell carcinoma, 9 brain tumor, 6 biliary tract, and 4 pancreatic carcinoma cell lines. These SNU cell lines have been distributed to biomedical researchers domestic and worldwide through the KCLB (Korean Cell Line Bank), and have proven to be of value in various scientific research fields. The characteristics of these cell lines have been reported in over 180 international journals by our laboratory and by many other researchers from 1987. In this paper, the cellular and molecular characteristics of SNU human cancer cell lines are summarized according to their genetic and epigenetic alterations and functional analysis.
