The Prevalence and Risk Factors of Drug Resistant Pulmonary Tuberculosis Investigated at One University Hospital in Seoul.
10.4046/trd.2005.58.3.243
- Author:
Do Kyun KIM
1
;
Mi Ok KIM
;
Tae Hyung KIM
;
Jang Won SOHN
;
Ho Joo YOON
;
Dong Ho SHIN
;
Sung Soo PARK
Author Information
1. Departments of Internal Medicine, Hanyang University Medical School, Korea. parks@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Pulmonary tuberculosis treatment;
Drug resistance;
Risk factor;
Korea
- MeSH:
Academic Medical Centers;
Drug Resistance;
Drug Resistance, Multiple;
Ethambutol;
Humans;
Isoniazid;
Korea;
Prevalence*;
Pyrazinamide;
Rifampin;
Risk Factors*;
Seoul*;
Streptomycin;
Treatment Failure;
Tuberculosis;
Tuberculosis, Multidrug-Resistant;
Tuberculosis, Pulmonary*
- From:Tuberculosis and Respiratory Diseases
2005;58(3):243-247
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The prevalence of tuberculosis is slowly decreasing in Korea. However, the drug-resistance of pulmonary tuberculosis is a major risk factor of treatment failure. Moreover, the National Surveillance System has recently been discontinued. Therefore, a continuous survey is necessary for the exact detection of the rate of drug resistance. We studied the recent 4-year drug resistance rate of tuberculosis at a single University hospital in Seoul. MATERIALS AND METHODS: The study included 239 pulmonary tuberculosis patients performed with a tuberculosis culture and a drug-sensitivity test at Hanyang University Medical Center from March 1999 to March 2003. RESULTS: Of the 239 patients included in the study during the 4-year period, 52 patients showed resistance to one or more anti-tuberculosis drug (21.8%). The rate of multi-drug resistance was 12.6%. The resistance rates to isoniazid, rifampin, ethambutol, streptomycin and pyrazinamide were 18.4%, 13.8%, 11.7%, 6.7% and 8.4%, respectively. Ninety patients had a history of previous anti-tuberculosis treatment, and the rates of the overall drug resistance and multi-drug resistance of these patients were 36.7% and 25.6%, respectively. The patients with drug-resistance showed a higher rate of a previous tuberculosis treatment history (63.5%) than the drug-sensitive group patients (30.5%). CONCLUSION: The rate of drug resistant tuberculosis is 21.8%, and multi-drug resistant tuberculosis is 12.6%. The rate of drug resistance is higher in those previously treated for tuberculosis.
