A Case of Necrolytic Migratory erythema Induced by a Pancreatic Insufficiency.
- Author:
Min Soo JANG
1
;
Yeong Jin KIM
;
Young Soo CHAE
;
Kee Suck SUH
;
Sang Tae KIM
Author Information
1. Department of Dermatology, Kosin University Medical School, Pusan, Korea.
- Publication Type:Case Report
- Keywords:
Necrolytic migratory erythema;
Pancreatic insufficiency
- MeSH:
Adult;
Amino Acids;
Anemia;
Celiac Disease;
Edema;
Erythema;
Exocrine Pancreatic Insufficiency*;
Glossitis;
Glucagon;
Glucagonoma;
Head;
Humans;
Infusions, Intravenous;
Islets of Langerhans;
Liver Cirrhosis;
Male;
Necrolytic Migratory Erythema*;
Necrosis;
Pallor;
Pancreatitis, Chronic;
Rupture;
Stomatitis;
Weight Loss;
Zinc
- From:Korean Journal of Dermatology
1996;34(1):166-170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Necrolytic migratory erythema is a cutaneous reaction pattern with specific histopathologic features that is typically associated with a functioning pancreatic islet cell neoplasm such as a glucagonoma. However, cases without. glucagonoma have also been reported, such as, liver cirrhosis, chronic pancreatitis, celiac sprue etc. Other clinical features include anemia, glossitis and weight loss. We report a case of neccrolytic migratory erythema induced by a pancreatic insufficiency without glucagonoma. A 43-year-old male was seen at our department because of rnultiple erythematous, desquamative and erosive patches on the whole body for 1 month. He also had weight loss(25Kg) and stomatitis. Seven years previously he had a Whipple's procedure for a pancreatic head rupture. The laboratory data showed a low protein and zinc level, and high glucagon level. Histopathologic findings of the case showed epidermal edema and pallor, and superficial epiderrnal necrosis. The patient improved progressively after intravenous infusion of amino acids with a pancreatic enzyme supplementation.
