Threshold of Nuchal Translucency for the Detection of Chromosomal Aberration: Comparison of Different Cut-offs.
10.3346/jkms.2006.21.1.11
- Author:
Min Hyoung KIM
1
;
Su Hyun PARK
;
Hye Jin CHO
;
June Seek CHOI
;
Joo Oh KIM
;
Hyun Kyong AHN
;
Joong Sik SHIN
;
Jung Yeol HAN
;
Moon Young KIM
;
Jae Hyug YANG
Author Information
1. Department of Obstetrics & Gynecology, Samsung Cheil Hospital & Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jhy60408@yahoo.co.kr
- Publication Type:Original Article ; Comparative Study
- Keywords:
Nuchal Translucency Measurement;
Sensitivity & Specificity;
Chromosome Aberrations
- MeSH:
Adult;
*Chromosome Aberrations;
Chromosome Disorders/diagnosis;
Comparative Study;
Female;
Fetal Diseases/*diagnosis/genetics;
Humans;
Mass Screening/methods;
Nuchal Translucency Measurement/*methods;
Pregnancy;
Sensitivity & Specificity
- From:Journal of Korean Medical Science
2006;21(1):11-14
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study evaluated the sensitivities and false positive rates of the screening test using ultrasonographic measurement of thickness of nuchal translucency (NT) with different cut-offs for chromosomal aberration in a Korean population. We included 2,570 singleton pregnancies undergoing ultrasound between 11 weeks and 14 weeks of gestation in this study. We analyzed the sensitivities of NT alone for screening chromosomal aberration using three cut-offs -2.5 mm, 3.0 mm, and 95th percentile for each crown rump length (CRL). There were 31 chromosomal aberrations (1.2%) including 12 cases of trisomy 21. The numbers of chromosomal aberrations that were detected by NT with different cut-offs of 2.5 mm, 3.0 mm and the 95th percentile CRL were 22, 18 and 23, respectively. At a threshold of 2.5 mm, the sensitivity and the false positive rate for total chromosomal aberrations were 67.7% and 6.3%, respectively. At 3.0 mm, those were 54.8% and 3.5%, respectively. At the 95th percentile CRL, those were 70.9% and 5.8%, respectively. The use of CRL-dependent cut-offs for nuchal translucency improves the detection of chromosomal aberrations when compared to fixed cut-offs in a Korean population.
