Impact of Circulating TGF-beta and IL-10 on T Cell Cytokines in Patients with Asthma and Tuberculosis.
10.3346/jkms.2006.21.1.30
- Author:
An Soo JANG
1
;
Sung Woo PARK
;
Mi Hyun AHN
;
Jong Sook PARK
;
Do Jin KIM
;
June Hyuk LEE
;
Choon Sik PARK
Author Information
1. Asthma and Allergy Research Group, Allergy and Respiratory Diseases, Soonchunhyang University College of Medicine, Seoul, Korea. mdcspark@unitel.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Asthma;
Tuberculosis;
T-Lymphocytes;
Interleukin-10;
Transforming Growth Factor beta
- MeSH:
Adult;
Asthma/*blood/immunology;
Cytokines/*blood;
Female;
Humans;
Interferon Type II/blood;
Interleukin-10/blood;
Interleukin-4/blood;
Male;
Research Support, Non-U.S. Gov't;
Respiratory Function Tests;
Skin Tests;
Th1 Cells/*metabolism;
Th2 Cells/*metabolism;
Transforming Growth Factor beta/blood;
Tuberculin Test;
Tuberculosis/*blood/immunology
- From:Journal of Korean Medical Science
2006;21(1):30-34
- CountryRepublic of Korea
- Language:English
-
Abstract:
Regulatory T cells, which stimulate or inhibit the effector functions of distinct T cell subsets, are critical in the control of the immune response. We investigated the effect of TGF-beta and IL-10 on T cell subsets according to the Th1/Th2 immune status. Sixty-two patients with asthma and 38 patients with pulmonary tuberculosis were included. Allergy skin tests, tuberculin tests, and chest radiography were performed. The levels of circulating IL-4, IFN-gamma, TGF-beta1, and IL-10 were measured using ELISA. The level of TGF-beta1 was higher in patients with asthma than in those with tuberculosis, but the IL-10 levels were the same between the asthma and tuberculosis groups. Atopy was unrelated to the tuberculin response. The IFN-gamma level was correlated with the IL-10 level, and the level of IL-4 was unrelated to the IL-10 or TGF-beta1 level. The level of IL-10 was higher in the negative tuberculin reactors than in the positive tuberculin reactors among patients with asthma, and TGF-beta1 was higher in the positive tuberculin reactors than in the negative tuberculin reactors among patients with tuberculosis. These results demonstrate that the regulatory effects of circulating TGF-beta and IL-10 on T cell cytokines may be different between Th2-type asthma and Th1 tuberculosis.
