Analysis of the Monocyte Chemoattractant Protein 1 -2518 Promoter Polymorphism in Korean Patients with Alopecia Areata.
10.3346/jkms.2006.21.1.90
- Author:
Seok Beom HONG
1
;
Sheng Yu JIN
;
Hae Jeong PARK
;
Joo Ho JUNG
;
Woo Young SIM
Author Information
1. Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea. wysim@khmc.or.kr
- Publication Type:Original Article
- Keywords:
Alopecia Areata;
Chemokines;
MCP 1 Protein, human;
Polymorphism, Genetic
- MeSH:
Adolescent;
Adult;
Alleles;
Alopecia Areata/*genetics;
Case-Control Studies;
Female;
Gene Frequency;
Genetic Predisposition to Disease/genetics;
Genotype;
Humans;
Korea;
Male;
Middle Aged;
Monocyte Chemoattractant Protein-1/*genetics;
*Polymorphism, Single Nucleotide;
Promoter Regions (Genetics)/*genetics
- From:Journal of Korean Medical Science
2006;21(1):90-94
- CountryRepublic of Korea
- Language:English
-
Abstract:
Monocyte chemoattractant protein-1 (MCP-1) levels are increased in scalp lesions of patients with alopecia areata (AA), suggesting a role in the development of AA. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. We investigated whether the presence of these polymorphisms were associated with AA in Korean population. 145 Korean patients with AA, 246 healthy subjects without clinical evidence of AA were screened for genotype with a PCR-based assay. In the AA patients the frequency of the A and G alleles was 40.3 and 59.7%, respectively and the distribution of the A/A, A/G and G/G genotypes was 19.3, 42.1 and 38.6%, respectively. Amongst the controls the frequency of the A and G alleles was 39.8 and 60.2%, and the distribution of the A/A, A/G, G/G genotypes in the same group was 17.5, 44.7 and 37.8%, respectively. There was no significant difference in the allele frequencies and genotype distributions between the patients and the controls (p=0.889, p=0.848, respectively). Our data indicates that no association exists between the -2518A/G polymorphism of the MCP-1 gene and susceptibility to alopecia areata.
