Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats.
10.14245/kjs.2015.12.2.55
- Author:
Seong Jun RYU
1
;
Dal Sung RYU
;
Jong Yul KIM
;
Jeong Yoon PARK
;
Kyung Hyun KIM
;
Dong Kyu CHIN
;
Keun Su KIM
;
Yong Eun CHO
;
Sung Uk KUH
Author Information
1. Department of Neurosurgery, The Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. kuhsu@yuhs.ac
- Publication Type:Original Article
- Keywords:
Animal model;
Osteoporosis;
Male;
Orchiectomy;
Bone mineral density;
Femur
- MeSH:
Animals;
Bone Density*;
Female;
Femur;
Humans;
Incidence;
Male;
Models, Animal;
Multiple Endocrine Neoplasia Type 1;
Orchiectomy*;
Osteoporosis;
Rats*;
Rats, Sprague-Dawley
- From:Korean Journal of Spine
2015;12(2):55-59
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking. METHODS: Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups: a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery. RESULTS: Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery. CONCLUSION: 8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.
