Maintenance of CD8+T-cell anergy by CD4+CD25+ regulatory T cells in chronic graft-versus-host disease.
- Author:
Juyang KIM
1
;
Hye J KIM
;
Woon S CHOI
;
Seok H NAM
;
Hong R CHO
;
Byungsuk KWON
Author Information
1. The Immunomodulation Research Center, University of Ulsan, Ulsan, Korea. bkwon@mail.ulsan.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
apoptosis;
B-lymphocytes;
clonal anergy;
graft vs host disease;
T-lymphocytes, cytotoxic;
T- lymphocytes, regulatory
- MeSH:
T-Lymphocytes, Regulatory/*immunology;
Mice, Inbred DBA;
Mice;
Interleukin-2 Receptor alpha Subunit/*metabolism;
Immune Tolerance/physiology;
Graft vs Host Disease/*immunology;
Female;
Clonal Anergy/*physiology;
Chronic Disease;
CD8-Positive T-Lymphocytes/*immunology;
CD4-Positive T-Lymphocytes/*immunology;
Animals
- From:Experimental & Molecular Medicine
2006;38(5):494-501
- CountryRepublic of Korea
- Language:English
-
Abstract:
In a murine model of systemic lupus erythematosus (SLE)-like chronic graft-versus-host disease (cGVHD), donor CD8+T cells rapidly fall into anergy to host cells, while donor CD4+T cells hyperactivate B cells and break B-cell tolerance to self-Ags in the recipient mouse. The functional recovery of donor CD8+T cells can result in the conversion of cGVHD to acute GVHD (aGVHD), indicating that donor CD8+T-cell anergy is a restriction factor in the development of cGVHD. In this report, we present evidence that donor CD4+CD25+regulatory T cells (T(reg) cells) are critical in maintaining the donor CD8+T-cell anergy and thus suppressing the development of aGVHD in mice that are naturally prone to cGVHD. Our results provide a novel insight into the role of T(reg) cells in determining cGVHD versus aGVHD.
