Therapeutic Effect of Minocycline on Confluent and Reticulated Papillomatosis.
- Author:
Sung Wook SHIN
;
Jong Gu KIM
;
Seung Hoon CHA
;
Seok Don PARK
- Publication Type:Original Article
- Keywords:
Confluent and reticulated papillomatosis;
Minocycline
- MeSH:
Humans;
Minocycline*;
Papilloma*;
Pruritus;
Recurrence;
Skin
- From:Korean Journal of Dermatology
1998;36(2):204-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Confluent and reticulate papillomatosis(CRP) of Gougerot and Carteaud is an uncommon disorder of unknown cause for which a variety of treatments have been proposed. OBJECTIVE: We attempted to evaluate the therapeutic effect of oral minocycline for CRP. METHOD: Nine patients(age range, 14 to 38; mean age, 21years) with CRP were included in this study. They took minocycline 100mg daily. The therapeutic effect was evaluated weekly by 5 scoring systems according to the percentage clearing of the skin lesion: poor (score 1), <25% clearing; fair (score 2), 26-50%; good (score 3), 51-75%; excellent (score 4), 76-95%, clear(score 5), >95%. RESULTS: Two out of 9 patients showed complete clearing(score 5) of the skin lesions within 2 weeks. Seven patients revealed incomplete clearing(score 4) within 3 to 8 weeks. The mean scoring for 9 CRP patients was 4.2. Recurrences were noted in two patients at 24 and 26 months, respectively, but they responded to re-treatment with minocycline. The patients did not show any adverse reactions apart from two patients who developed mild pruritus. CONCLUSION: We recommend minocycline as the first choice of treatment for CRP because minocycline is safe, economic and effective.
