Changes in Histopathology and Tumor Necrosis Factor-αLevels in the Hearts of Rats Following Asphyxial Cardiac Arrest.
- Author:
Jung Hoon LEE
1
;
Tae Kyeong LEE
;
In Hye KIM
;
Jae Chul LEE
;
Moo Ho WON
;
Joon Ha PARK
;
Ji Hyeon AHN
;
Myoung Chul SHIN
;
Taek Geun OHK
;
Joong Bum MOON
;
Jun Hwi CHO
;
Chan Woo PARK
;
Hyun Jin TAE
Author Information
1. Department of Emergency Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea. bonaeboa@naver.com
- Publication Type:Original Article
- Keywords:
Cardiac arrest;
Heart;
TNF-alpha
- MeSH:
Animals;
Heart Arrest*;
Heart*;
Humans;
Male;
Necrosis*;
Rats*;
Rats, Sprague-Dawley;
Resuscitation;
Survival Rate;
Tumor Necrosis Factor-alpha
- From:Journal of the Korean Society of Emergency Medicine
2017;28(5):449-456
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have a return of spontaneous circulation (ROSC) after the CA. The aim of this study was to examine the histopathology and inflammatory response in the heart during post CA syndrome. METHODS: Asphyxial CA was induced in male Sprague-Dawley rats and the survival rate of the rats was determined during the post resuscitation phase. RESULTS: Survival of the rats decreased after CA: 66.7% at 6 hours, 36.7% at 1 day, and 6.7% at 2 days after the ROSC following CA. The rats were sacrificed at 6 hours, 12 hours, 1 day, and 2 days after the ROSC, and their heart tissues were examined. Histopathological scores increased at 12 hours post CA. Afterwards, the histopathological changes were not significant. In addition, the levels of tumor necrosis factor-αimmunoreactivity increased gradually after CA. CONCLUSION: The survival rate of the rats 2 days post CA was very low, even though the histopathological and inflammatory changes in the heart were not pronounced in the early stages following the CA.
