A Case of Hepatocellular Carcinoma in a Patient with Crohn's Disease.
10.3904/kjm.2015.88.4.424
- Author:
Seung Hyeon JANG
1
;
Jee Hyun KIM
;
Jae Woo LEE
;
June Young LEE
;
Young Youn CHO
;
Won Mook CHOI
;
Hyun Chae JUNG
Author Information
1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea. hyunchae@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Hepatocellular carcinoma;
Crohn disease;
Azathioprine;
Infliximab
- MeSH:
Abscess;
Adult;
Azathioprine;
Biopsy;
Carcinoma, Hepatocellular*;
Catheter Ablation;
Cholangitis, Sclerosing;
Colon;
Crohn Disease*;
Follow-Up Studies;
Glycogenolysis;
Hepatitis, Chronic;
Humans;
Immunosuppressive Agents;
Korea;
Liver;
Liver Cirrhosis;
Pathology;
Infliximab
- From:Korean Journal of Medicine
2015;88(4):424-429
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hepatocellular carcinomas (HCCs) in patients with Crohn's disease (CD) without underlying chronic hepatitis or liver cirrhosis are extremely rare. Previously reported cases occurred in patients who had developed CD at a young age and had been treated with immunosuppressive agents long-term. We herein report the first case of HCC in a 34-year-old patient with CD in Korea. The patient was treated with azathioprine for 14 years and had undergone repeated surgeries for CD. During the follow-up period, the patient was hospitalized for colon perforation and pericolic abscess formation. Computed tomography showed a liver mass, and HCC was diagnosed based on liver biopsy. The patient underwent right hemicolectomy for colon perforation and transcatheter arterial chemoembolization followed by radiofrequency ablation for the HCC. The present case is similar to previously reported cases with the exception of the liver pathology findings, which exhibited neither primary sclerosing cholangitis nor focal hepatic glycogenolysis.
