Molecular Epidemiology of Korean Isolates of Molluscum Contagiosum Virus.
- Author:
Jee Ho CHOI
;
Kyu Han KIM
;
Seong Beom KIM
;
Jung Wha SUH
;
Jai Kyoung KOH
;
Kyung Jeh SUNG
- Publication Type:Original Article
- Keywords:
Molluscum Contagiosum Virus-l;
MCV-2;
Restriction Endonucleae Analysis
- MeSH:
Dermatitis, Atopic;
DNA;
DNA Restriction Enzymes;
Humans;
Molecular Epidemiology*;
Molluscum contagiosum virus*;
Molluscum Contagiosum*
- From:Korean Journal of Dermatology
1994;32(5):763-769
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recent restriction enclonuclease analysis studies hsve revealed that MCV DNA can be classified into two major types, designated MCV-1 and MCV-2, by th:ir restriction enzyme cleavsge patterns. In earlier reports of MCV DNA analysis, MCV-2 was the main virus type found in genital lesions. However many recent studies cienied the relationship between virus type and anatomical distribution. OBJECTIVE: The purpose of this study was to examine the ratio of MCV-l to MCV-2 in Korean isolates of MCV DNA and the relationship between MCV subtypes and with clinical features such as anatomical location, age, sex, numiber of lesions, and atopic dermatitis. METHODS: MCV DNA extrated from 112 cases of Korean patients waa examined by restriction endonuclease analysis using Brtm HI. RESULTS: 1. MCV-1 was found in 108 of 112 (96.4%) patients and MCV-2 in of 112 (3.6%) patients. The ratio of MCV-1 to MCV-2 wss 28:1. 2. There was no significant ciprrelation between MCV subtypes and the age, sex, number of lesions, atopic dermatitis, and anatoimic loction. 3. Lesions induced by MCV-1 MCV-2 were indistinguishable on the brsis of size and form. CONCLUSION: This study showis that the ratio of MCV-1 to MCV-2 was 28:1 in Korean molluscum contagiosum patients and there was no relationship between MCV subtyies and lesional morphology or snatomical distribution.
