Postoperative irradiation after implant placement: A pilot study for prosthetic reconstruction.
- Author:
Re Mee DOH
1
;
Sungtae KIM
;
Ki Chang KEUM
;
Jun Won KIM
;
June Sung SHIM
;
Han Sung JUNG
;
Kyeong Mee PARK
;
Moon Kyu CHUNG
Author Information
- Publication Type:Original Article
- Keywords: Postoperative radiotherapy; Head and neck cancer; Local irradiation; Implant; Empty lacuna
- MeSH: Bone Density; Head and Neck Neoplasms; Humans; Molar; Osseointegration; Pilot Projects*; Prostheses and Implants; Radiotherapy; Rats, Sprague-Dawley
- From:The Journal of Advanced Prosthodontics 2016;8(5):363-371
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: On maxillofacial tumor patients, oral implant placement prior to postoperative radiotherapy can shorten the period of prosthetic reconstruction. There is still lack of research on effects of post-implant radiotherapy such as healing process or loading time, which is important for prosthodontic treatment planning. Therefore, this study evaluated the effects of post-implant local irradiation on the osseointegration of implants during different healing stages. MATERIALS AND METHODS: Custom-made implants were placed bilaterally on maxillary posterior edentulous area 4 weeks after extraction of the maxillary first molars in Forty-eight Sprague-Dawley rats. Experimental group (exp.) received radiation after implant surgery and the other group (control) didn't. Each group was divided into three sub-groups according to the healing time (2, 4, and 8 week) from implant placement. The exp. group 1, 2 received 15-Gy radiation 1 day after implant placement (immediate irradiation). The exp. group 3 received 15-Gy radiation 4 weeks after implant placement (delayed irradiation). RESULTS: The bone mineral density (BMD) was significantly lower in the immediate irradiation groups. BMD was similar in the delayed irradiation group and the control group. The irradiated groups exhibited a lower bone-to-implant contact ratio, although the difference was not statistically significant. The irradiated groups also exhibited a significantly lower bone volume and higher empty lacuna count than the control groups. No implant failure due to local irradiation was found in this study. CONCLUSION: Within the limits of this study, the timing of local irradiation critically influences the bone healing mechanism, which is related to loading time of prostheses.
