Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits.
- Author:
Kye Hyun KIM
1
;
Hee Yeon WOO
;
Se Won LIM
Author Information
1. Department of Obstetrics Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Anxiety;
Anxiety sensitivity;
Polymorphism;
Serotonin 2A receptor
- MeSH:
Adolescent;
Alleles;
Anxiety;
Female;
Genotype;
Humans;
Polymerase Chain Reaction;
Receptor, Serotonin, 5-HT2A;
Serotonin*
- From:Psychiatry Investigation
2008;5(4):244-246
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The aim of this study was to investigate the relationship between the -1438A/G polymorphism of serotonin receptor 2A (5HTR2A) and anxiety-related traits in Korean adolescent females. METHODS: A total of 174 Korean adolescent females were tested for the -1438A/G polymorphism of 5HTR2A using polymerase chain reaction (PCR)-based methods. Anxiety-related traits were evaluated using the Anxiety Sensitivity Index (ASI) and the trait form of the Spielberg State-Trait Anxiety Inventory (T-STAI). RESULTS: There was no difference between the genotypes with respect to scores pertaining to anxiety-related traits. Although the G allele carriers (GG or AG genotype) scored lower on the psychological subscale of the ASI (4.76+/-3.00 vs 5.98+/-4.00, p=0.038), this difference was not significant after Bonferroni correction. CONCLUSION: These findings suggest that the -1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety.
