The Impact of Elderly Donor in Renal Transplantation.
- Author:
Pil Kyung PARK
1
;
Oh Jung KWON
;
Chong Myung KANG
Author Information
1. Department of Surgery, College of Medicine, Hanyang University, Seoul, Korea. ojkwon@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Kidney transplantation;
Elderly donor;
Graft survival rate
- MeSH:
Aged;
Creatinine;
Delayed Graft Function;
Graft Survival;
HLA-DR Antigens;
Humans;
Kidney;
Kidney Transplantation;
Rejection (Psychology);
Retrospective Studies;
Tissue Donors;
Transplants
- From:The Journal of the Korean Society for Transplantation
2008;22(1):66-69
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Kidney transplantation from elderly donors is controversial because of decline of received renal function and increased risk of perioperative complication. METHODS: We retrospectively reviewed the records of the 676 patients from 1985 to 2006 in our center. 42 (6.2%) donors were > or =60 years old, and constitue the group 1, and 634 donors (93.8%) were <60 years old (group 2). We analysis graft survival, preoperative and postoperative creatinine, creatinine clearance, acute rejection rate, infection rate, delayed graft fucntion rate, HLA matching between groups. RESULTS: The average donor age in group 1 is 62.8 yr (60~73) and 39.3 yr (16~59) in group 2. Graft survival rate at 1, 5 and 10 years were 92%, 71%, 56% in group 1 vs 92%, 77%, 62% in group 2 (P=0.0831). There was no difference of graft survival between groups. In preoperative serum creatinine or postoperative days 3, 30 creatinine there was not difference between groups. Infection rate was 9.5% (4 patients) in group 1 vs. 7.3% (46 patients) in group 2. Acute rejection rate was 28.6% (12 patients) vs. 30.9% (196 patients). Delayed graft function (DGF) rate was 7.1% (3 patients) vs. 9.0% (57 patients). HLA-AB matching was 1.86 vs. 1.78 and HLA-DR matching was 1.12 vs. 1.06. All were not significantly different between groups. But the elderly donor group has a lower creatinine clearance at postoperative 3, 30 days (P=0.0422, 0.0231). CONCLUSION: The short and long-term survival of kidney transplantation from elderly donors (> or =60) are similar to younger donors (<60). We suggest that use of elderly donors may help to expand the donor pool in kidney transplantation.
