Comparison of Clinical Findings between Autoimmune Pancreatitis with Bile Duct Involvement and Primary Sclerosing Cholangitis.
- Author:
Ja Young KIM
1
;
Myung Hwan KIM
;
Ji Hoon JUNG
;
Ju Hyung SONG
;
Hyoung Chul OH
;
Seung Hyun KWON
;
Tae Yoon LEE
;
Sang Soo LEE
;
Dong Wan SEO
;
Sung Koo LEE
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. mhkim@amc.seoul.kr
- Publication Type:Case Reports ; Comparative Study ; English Abstract
- Keywords:
Autoimmune pancreatitis;
Primary sclerosing cholangitis;
Cholangiopancreatography, endoscopic retrograde
- MeSH:
Autoimmune Diseases/*diagnosis/pathology/radiography;
Bile Ducts/pathology;
*Cholangiography;
Cholangiopancreatography, Endoscopic Retrograde;
Cholangitis, Sclerosing/*diagnosis/pathology/radiography;
Diagnosis, Differential;
Female;
Humans;
Immunoglobulins/blood;
Male;
Pancreatitis/*diagnosis/*immunology/pathology;
Retrospective Studies;
Sex Factors
- From:The Korean Journal of Gastroenterology
2006;48(2):104-111
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGOUND/AIMS: The involvement of bile ducts is frequently reported in autoimmune pancreatitis (AIP), which seem to have similar features to primary sclerosing cholangitis (PSC). Recent systematic comparative studies about these diseases are rare in Korea. METHODS: We retrospectively analyzed 26 patients with AIP with bile duct involvement and 30 patients with classic PSC who were diagnosed during the last decade. RESULTS: The mean age of patients was significantly higher in AIP than PSC at the time of diagnosis. There was a preponderance of men in both group, which was more prominent in AIP. The most common symptom in patients with AIP was jaundice, but PSC patients usually visited hospitals due to incidentally detected abnormal liver function tests. Most (26/31) of AIP had bile duct involvement. All of these patients showed narrowing of intrapancreatic common bile ducts and one patient exhibited hilar involvement as well. About 80% of PSC had both intra- and extrahepatic ducts involvement, and the characteristic features involve multifocal strictures. AIP patients showed improvement with steroid treatment, however, most PSC patients showed clinical deterioration. CONCLUSIONS: The clinical and cholangiographic findings of patients with AIP and PSC have many different characteristics. Therefore, further study of two diseases is required for the proper diagnosis and management.
