Clinical Features of Neuroendocrine Tumor of the Pancreas: Single Center Study.
- Author:
Tae Wook KANG
1
;
Kyu Taek LEE
;
Min Kyu RYU
;
Won MOON
;
Sang Soo LEE
;
Sun Young LEE
;
Ji Young HWANG
;
Jong Kyun LEE
;
Jin Seok HEO
;
Seong Ho CHOI
;
Sang Heum KIM
;
Seung Woon PAIK
;
Jong Chul RHEE
Author Information
1. Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ktlee@smc.samsung.co.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Pancreas;
Neuroendocrine tumors
- MeSH:
Adult;
Diabetes Mellitus/pathology;
Female;
Humans;
Male;
Middle Aged;
Neoplastic Cells, Circulating/pathology;
Neuroendocrine Tumors/complications/*diagnosis;
Pancreatic Ducts/abnormalities/pathology;
Pancreatic Neoplasms/complications/*diagnosis;
Whipple Disease/complications
- From:The Korean Journal of Gastroenterology
2006;48(2):112-118
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Pancreatic neuroendocrine tumors (PNET) are rare and manifest as functioning tumor (FT) or non-functioning tumor (NFT). Although malignant changes are observed in some cases, its prognosis is better than pancreatic cancer. We evaluated clinicoradiologic features and prognosis of FT and NFT. In addition, we tried to find the predictive factors for the recurrence of NFT after resection. METHODS: Between October 1994 and June 2004, we retrospectively evaluated the clinicopathologic features and prognosis of 12 cases of FT and 31 cases of NFT diagnosed by surgical pathology at single medical center in Korea. RESULTS: PNET included 6 insulinomas, 4 gastrinomas, 1 glucagonoma, 1 somatostatinoma and 31 NFT. The major clinical manifestations were neuroglycopenic symptoms (100%) in insulinoma, abdominal ulcer symptoms (75%) in gastrinoma, dermatitis (100%) in glucagonoma, steatorrhea (100%) in somatostatinoma, and abdominal discomfort or pain (45%) in NFT. NFT was located more proximally when compared to FT (p=0.023). NFT showed more malignant (64.5%) behavior compared to FT (41.7%) despite the lack of statistical significance. Curative resections were done without postoperative death in 38 cases. Six cases of NFT (21.4%) and 1 case of FT (10%) recurred with an average of 26.5 months. In the recurrent NFT, the findings of diabetes mellitus (p=0.010), abnormal pancreatic duct (p=0.026), Whipple's operation (p=0.013) and tumor emboli (p=0.03) were more common than in non-recurrent NFT. CONCLUSIONS: FT and NFT showed different clinicoradiologic features. In addition, NFT should be monitored more carefully because of frequent recurrence.
