Treatment of Molluscum Contagiosum with High Dose Cimetidine Therapy.
- Author:
Jae Yong CHANG
1
;
Kee Yang CHUNG
;
Woo Gil CHUNG
Author Information
1. Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. chan71@hanmail.net
- Publication Type:Original Article
- Keywords:
Cimetidine;
High dose therapy;
Molluscum contagiosum
- MeSH:
Cimetidine*;
Dermatitis, Atopic;
Eyelids;
Female;
Humans;
Male;
Molluscum Contagiosum*;
Peptic Ulcer;
Receptors, Histamine
- From:Korean Journal of Dermatology
2006;44(8):937-941
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Molluscum contagiosum is often a difficult problem for dermatologists to treat. Cimetidine is a H2 histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. The use of cimetidine in the treatment of molluscum contagiosum has been reported previously using a dose of 40 mg/kg/day, and has the advantage of being painless and easy to administer, especially for recurrent, extensive, facial and eyelid lesions. OBJECTIVE: The purpose of this study was to evaluate the clinical effects of high dose cimetidine therapy for molluscum contagiosum. METHODS: Twenty patients with molluscum contagiosum were treated using high dose cimetidine therapy (14 females, 6 males; age range 2~16 years). RESULTS: Of the 20 patients who completed the study, 12 patients (60%) showed complete remission, 3 patients (15%) showed partial remission and 5 patients (25%) showed no response. Five out of 8 patients with atopic dermatitis showed complete remission and one showed partial remission. Of the 12 patients without atopic dermatitis, 7 showed complete remission and 2 showed partial remission. CONCLUSION: High dose cimetidine therapy is an effective treatment modality for molluscum contagiosum, and has no severe adverse effects.
