Possible Apoptotic Mechanisms in the Vesiculation Process of Pemphigus, Bullous Pemphigoid, and Epidermolysis Bullosa Acquisita.
- Author:
Ji Goo OH
1
;
Joo Hyoung KANG
;
Se Jin HWANG
;
Kyu Uang WHANG
;
Chang Woo LEE
Author Information
1. Department of Dermatology, College of Medicine, Hanyang University, Seoul, Korea. cwlee@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Acantholysis;
Apoptosis;
Bullous pemphigoid;
Epidermolysis bullosa acquisita;
Pemphigus
- MeSH:
Acantholysis;
Apoptosis;
Autoantibodies;
Blister;
Cell Death;
Epidermis;
Epidermolysis Bullosa Acquisita*;
Epidermolysis Bullosa*;
Humans;
Keratinocytes;
Mucous Membrane;
Pemphigoid, Bullous*;
Pemphigus*;
Skin;
Skin Diseases, Vesiculobullous
- From:Korean Journal of Dermatology
2006;44(8):942-949
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Apoptosis, or programmed cell death, may participate with pathogenesis of intercellular detachment and loss of cell-matrix interaction. Autoimmune bullous dermatoses is an entity charaterized by bullous lesions of the skin and mucosa, and autoantibodies to the specific tissue components. OBJECTIVE: The purpose of this study was to investigate the induction of apoptosis in the lesional skin of pemphigus vulgaris (PV), pemphigus foliaceus (PF), bullous pemphigoid (BP), and epidermolysis bullosa acquisita (EBA). METHODS: Hoechst 33342 (bisbenzimide) staining and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining was performed to determine the induction of apoptosis in the lesional skin of each disease. RESULTS: In PV and PF, typical findings of apoptosis were observed in the lesional epidermis showing acantholysis. However, in BP and EBA, no apoptosis of the epidermis was observed. CONCLUSION: These results suggest that apoptosis is only associated with acantholysis of the epidermal keratinocytes, one of many components of pathogenesis in bullous disease, in patients with pemphigus.
