Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation.
10.3349/ymj.2007.48.2.317
- Author:
Jae Yong CHANG
1
;
Soo Chan KIM
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Yongdong Severance Hospital, Seoul, Korea. kimsc@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Carbamazepine;
Epstein-Barr virus;
hypersensitivity syndrome
- MeSH:
Virus Activation/*physiology;
Vacuoles/pathology;
Middle Aged;
Humans;
Herpesvirus 4, Human/drug effects/pathogenicity;
Female;
Erythema/etiology/virology;
Epstein-Barr Virus Infections/*physiopathology;
*Drug Hypersensitivity;
Anticonvulsants/*adverse effects
- From:Yonsei Medical Journal
2007;48(2):317-320
- CountryRepublic of Korea
- Language:English
-
Abstract:
We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein- Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English- language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.
