A Case of Vogt-Koyanagi-Harada Disease in a Patient With Graves Disease.
10.3341/kjo.2009.23.2.112
- Author:
Je Hyun SEO
1
;
Hyeong Gon YU
;
Hum CHUNG
Author Information
1. Department of Ophthalmology, College of Medicine, and Medical Research Center, Seoul National University, Seoul, Korea. hgonyu@ snu.ac.kr
- Publication Type:Case Report
- Keywords:
Drug-induced hypersensitivity;
Graves' disease;
Hyperthyroidism;
Iodine therapy;
Vogt-Koyanagi-Harada disease
- MeSH:
Adult;
Coloring Agents/administration & dosage;
Diagnosis, Differential;
Dose-Response Relationship, Drug;
Drug Therapy, Combination;
Female;
Fluorescein Angiography;
Follow-Up Studies;
Fundus Oculi;
Glucocorticoids/administration & dosage;
Graves Disease/*complications/diagnosis/drug therapy;
Humans;
Immunosuppressive Agents/administration & dosage;
Injections, Intravenous;
Iodides/administration & dosage;
Ophthalmic Solutions/administration & dosage;
Uveomeningoencephalitic Syndrome/*complications/diagnosis/drug therapy
- From:Korean Journal of Ophthalmology
2009;23(2):112-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
A case of Vogt-Koyanagi-Harada disease (VKH) that developed in a 36-year-old woman with Graves' disease was described. The patient was treated with Lugol's solution and presented with bilateral serous retinal detachment. She had also suffered from methimazole-induced hypersensitivity and steroid-induced myopathy. Fluorescein angiography showed multiple leakage points and a lumbar puncture revealed pleocytosis, which was compatible with VKH. High dose steroid pulse therapy was successful. Altered immune regulation associated with drug-induced hypersensitivity may contribute to the development of VKH in patients with Graves' disease.
