A Case of Apogeotropic Positional Nystagmus Associated With Anti-GD1b IgG Antibody.
- Author:
Seong Hae JEONG
1
;
Gun Sei OH
;
Dong Ick SHIN
;
Ji Soo KIM
Author Information
1. Department of Neurology, Eulji University School of Medicine, Eulji University Hospital, Daejeon, Korea. mseaj@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Anti-GD1b IgG antibody;
Apogeotropic nystagmus;
Positron emission tomography
- MeSH:
Cerebellar Ataxia;
Cerebellum;
Female;
Humans;
Immunoglobulin G;
Nystagmus, Physiologic;
Peripheral Nerves;
Positron-Emission Tomography;
Quadriplegia
- From:Journal of the Korean Balance Society
2008;7(1):73-76
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The binding of anti-GD1b IgG antibody to the cerebellar granular area or spinocerebellar Ia fibers in the peripheral nerves may cause the prominent cerebellar ataxia, mild quadriparesis and sensory dominant neuropathy. A 31-year woman presented with severe cerebellar ataxia and prominent apogeotropic positional nystagmus/vertigo. Increased anti-GD1b antibody IgG in her serum was noted. 18F-flurodeoxyglucose positron emission tomography (FDG-PET) showed decreased uptake in cerebellum. It is the first case of central positional nystagmus with anti-GD1b IgG antibody.