Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage.
10.4062/biomolther.2015.005
- Author:
Xia HAN
1
;
Mei Jing PIAO
;
Ki Cheon KIM
;
Susara Ruwan Kumara MADDUMA HEWAGE
;
Eun Sook YOO
;
Young Sang KOH
;
Hee Kyoung KANG
;
Jennifer H SHIN
;
Yeunsoo PARK
;
Suk Jae YOO
;
Sungwook CHAE
;
Jin Won HYUN
Author Information
1. School of Medicine, Jeju National University, Jeju 690-756, Republic of Korea. jinwonh@jejunu.ac.kr
- Publication Type:Original Article
- Keywords:
Isorhamnetin;
Ultraviolet B;
Reactive oxygen species;
Human keratinocyte;
Programmed cell death
- MeSH:
Apoptosis;
Cell Death;
DNA;
Fruit;
Humans;
Keratinocytes*;
Plants, Medicinal;
Reactive Oxygen Species
- From:Biomolecules & Therapeutics
2015;23(4):357-366
- CountryRepublic of Korea
- Language:English
-
Abstract:
Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.
