Clinicopathologic Characteristics of Stage IV Early Gastric Cancer.
10.5230/jkgca.2008.8.3.136
- Author:
Min Kuk KIM
1
;
Ji Yeong AN
;
Min Gew CHOI
;
Jae Hyung NOH
;
Tae Sung SOHN
;
Sung KIM
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jhnoh@skku.edu
- Publication Type:Original Article
- Keywords:
Early gastric cancer;
Stage IV EGC;
Gastrectomy
- MeSH:
Adenocarcinoma;
Carcinoma, Signet Ring Cell;
Chemotherapy, Adjuvant;
Female;
Follow-Up Studies;
Gastrectomy;
Humans;
Lymph Nodes;
Male;
Neoplasm Metastasis;
Rare Diseases;
Recurrence;
Stomach Neoplasms;
Stroke
- From:Journal of the Korean Gastric Cancer Association
2008;8(3):136-140
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Stage IV early gastric carcinoma (EGC) is a rare disease. We report here on 10 cases of EGC that showed metastasis in more than 15 lymph nodes. MATERIALS AND METHODS: A total of 8354 cases of gastric carcinoma in patients who underwent surgical procedures between January 2001 and January 2007 at Samsung Medical Center were studied, and 10 cases were classified as stage IV EGC. We investigated their clinicopathologic characteristics. RESULTS: There were 5 males and 5 females. Their ages at operation ranged from 46 to 76 years with a mean age of 61. All of the 10 patients had undergone curative resection for gastric cancer. The pathological diagnosis confirmed that all of the patients had tumor confined to the submucosa. The median size of the tumors was 5.3cm and the mean number of dissected nodes was 45.5 with a mean number of 22.2 involved nodes. Six cases were classified as the diffuse type and 4 were classified as the intestinal type by Lauren's classification. Histologically, 3 cases were signet ring cell carcinoma, 3 were poorly differentiated, 2 were moderately differentiated and 2 were well differentiated adenocarcinoma. Endolymphatic invasion was found in 9 cases. The median follow-up was 31 months. Adjuvant chemotherapy was done in 9 patients, and the patient who did not receive chemotherapy died by cerebrovascular accident. 2 patient had recurrence of gastric cancer and 7 survived without recurrence. CONCLUSION: More cases should be collected and further studies on the molecular and cellular tumor characteristics are required to characterize these tumors that show aggressive lymphatic spread.
